about
DNAJC13 mutations in Parkinson diseaseChronic and acute LRRK2 silencing has no long-term behavioral effects, whereas wild-type and mutant LRRK2 overexpression induce motor and cognitive deficits and altered regulation of dopamine release.Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice.Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in miceLRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.
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description
researcher ORCID ID = 0000-0001-5728-7493
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wetenschapper
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name
Igor Tatarnikov
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Igor Tatarnikov
@en
Igor Tatarnikov
@es
Igor Tatarnikov
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type
label
Igor Tatarnikov
@ast
Igor Tatarnikov
@en
Igor Tatarnikov
@es
Igor Tatarnikov
@nl
prefLabel
Igor Tatarnikov
@ast
Igor Tatarnikov
@en
Igor Tatarnikov
@es
Igor Tatarnikov
@nl
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0000-0001-5728-7493