about
Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq.shRNA screening identifies JMJD1C as being required for leukemia maintenance.C/EBPalpha: a tumour suppressor in multiple tissues?C/EBPalpha in leukemogenesis: identity and origin of the leukemia-initiating cell.The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivoC/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitorsLack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors.Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating CellsEnhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null ProgenitorsThe splicing factor RBM25 controls MYC activity in acute myeloid leukemia[Transgenic mice as disease models]Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AMLHeterozygous loss of Srp72 in mice is not associated with major hematological phenotypes
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P50
description
researcher ORCID ID = 0000-0003-1742-5550
@en
wetenschapper
@nl
name
Mikkel Bruhn Schuster
@ast
Mikkel Bruhn Schuster
@en
Mikkel Bruhn Schuster
@es
Mikkel Bruhn Schuster
@nl
type
label
Mikkel Bruhn Schuster
@ast
Mikkel Bruhn Schuster
@en
Mikkel Bruhn Schuster
@es
Mikkel Bruhn Schuster
@nl
prefLabel
Mikkel Bruhn Schuster
@ast
Mikkel Bruhn Schuster
@en
Mikkel Bruhn Schuster
@es
Mikkel Bruhn Schuster
@nl
P31
P496
0000-0003-1742-5550