C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors
about
Dynamic equilibrium of heterogeneous and interconvertible multipotent hematopoietic cell subsets.Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivoC/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.The multifaceted functions of C/EBPα in normal and malignant haematopoiesis.Amplification of pico-scale DNA mediated by bacterial carrier DNA for small-cell-number transcription factor ChIP-seq.1,25-Dihydroxyvitamin D3 induces monocytic differentiation of human myeloid leukemia cells by regulating C/EBPβ expression through MEF2CThe +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors.In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and MyelopoiesisIsocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88.EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements.DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cellsAn autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.Nitric oxide has contrasting age-dependent effects on the functionality of murine hematopoietic stem cells.Inflammation-induced miRNA-155 inhibits self-renewal of neural stem cells via suppression of CCAAT/enhancer binding protein β (C/EBPβ) expression.Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.C/EBPα in normal and malignant myelopoiesis.Hematopoietic stem cells: concepts, definitions, and the new reality.Developmental Control of NRAMP1 (SLC11A1) Expression in Professional PhagocytesC/EBPα deregulation as a paradigm for leukemogenesis.The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia.The analysis of novel distal Cebpa enhancers and silencers using a transcriptional model reveals the complex regulatory logic of hematopoietic lineage specification.RUNX1 cooperates with FLT3-ITD to induce leukemia.C/EBPα is dispensable for the ontogeny of PD-1+ CD4+ memory T cells but restricts their expansion in an age-dependent manner.ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation.Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling.Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity
P2860
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P2860
C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
C/EBPα is required for long-te ...... ons in multipotent progenitors
@en
type
label
C/EBPα is required for long-te ...... ons in multipotent progenitors
@en
prefLabel
C/EBPα is required for long-te ...... ons in multipotent progenitors
@en
P2093
P2860
P50
P1433
P1476
C/EBPα is required for long-te ...... ons in multipotent progenitors
@en
P2093
Felicia K B Lauridsen
Marie S Hasemann
Philipp S Hoppe
Timm Schroeder
P2860
P304
P356
10.1371/JOURNAL.PGEN.1004079
P50
P577
2014-01-09T00:00:00Z