about
Small GTP-binding proteins in human endothelial cellsDisappearing acts of ADAMTS13Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis.T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site.Analysis of factor VIII inhibitors in a haemophilia A patient with an Arg593-->Cys mutation using phage display.Multiple B-cell clones producing antibodies directed to the spacer and disintegrin/thrombospondin type-1 repeat 1 (TSP1) of ADAMTS13 in a patient with acquired thrombotic thrombocytopenic purpura.Amino acid regions 572-579 and 657-666 of the spacer domain of ADAMTS13 provide a common antigenic core required for binding of antibodies in patients with acquired TTP.VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura.Improving on nature: redesigning ADAMTS13.Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells.Acquired thrombotic thrombocytopenic purpura. Development of an autoimmune response.Identification of N-linked glycosylation and putative O-fucosylation, C-mannosylation sites in plasma derived ADAMTS13.Acquired TTP: ADAMTS13 meets the immune system.CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides.Individual with subclinical atherosclerosis have impaired proliferation of blood outgrowth endothelial cells, which can be restored by statin therapyStorage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cellsFunctional architecture of Weibel-Palade bodies.The shear stress-induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel-Palade bodies.Biogenesis and exocytosis of Weibel-Palade bodies.Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.Content delivery to newly forming Weibel-Palade bodies is facilitated by multiple connections with the Golgi apparatus.Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factorStorage and regulated secretion of factor VIII in blood outgrowth endothelial cellsFactor VIII-specific B cell responses in haemophilia A patients with inhibitors.Requirements for immune recognition and processing of factor VIII by antigen-presenting cells.Hunting down factor VIII in the immunopeptidome.Enhanced uptake of blood coagulation factor VIII containing immune complexes by antigen presenting cells.Variation in baseline factor VIII concentration in a retrospective cohort of mild/moderate hemophilia A patients carrying identical F8 mutations.To serve and protect: The modulatory role of von Willebrand factor on factor VIII immunogenicity.Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation.von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.Von Willebrand factor targets IL-8 to Weibel-Palade bodies in an endothelial cell line.Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A.Monitoring storage induced changes in the platelet proteome employing label free quantitative mass spectrometry.Intracellular storage and regulated secretion of von Willebrand factor in quantitative von Willebrand diseaseFactor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking.Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry.
P50
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P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0003-4585-2621
@en
name
Jan Voorberg
@ast
Jan Voorberg
@en
Jan Voorberg
@es
Jan Voorberg
@nl
type
label
Jan Voorberg
@ast
Jan Voorberg
@en
Jan Voorberg
@es
Jan Voorberg
@nl
prefLabel
Jan Voorberg
@ast
Jan Voorberg
@en
Jan Voorberg
@es
Jan Voorberg
@nl
P106
P1153
7004528230
P31
P496
0000-0003-4585-2621