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Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerMyc deletion rescues Apc deficiency in the small intestinePHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.Cited1 deficiency suppresses intestinal tumorigenesis.The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.Normal stem cells in cancer prone epithelial tissues.Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers.Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cellsPartial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy.Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.Lgr5 joins the club of gastric stem cell markers in the corpus.Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.Wnt Signalling in Gastrointestinal Epithelial Stem Cells.Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.Responding to R-spondin: slit2 potentiates intestinal regeneration.Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant GrowthCorrection for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-"deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesisIL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc MutationsThe Function of Lgr5+ Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In VivoThe Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling
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description
researcher ORCID ID = 0000-0001-9568-4916
@en
wetenschapper
@nl
name
Toby J Phesse
@ast
Toby J Phesse
@en
Toby J Phesse
@nl
type
label
Toby J Phesse
@ast
Toby J Phesse
@en
Toby J Phesse
@nl
prefLabel
Toby J Phesse
@ast
Toby J Phesse
@en
Toby J Phesse
@nl
P106
P21
P31
P496
0000-0001-9568-4916