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The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowthGenetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.CRMP2 is necessary for Neurofibromatosis type 1 related pain.Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.CRMP2-Neurofibromin Interface Drives NF1-related Pain.Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical NeuronsA light-gated potassium channel for sustained neuronal inhibitionBlocking CRMP2 SUMOylation reverses neuropathic painActivity of T-type calcium channels is independent of CRMP2 in sensory neuronsA Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic painThe prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in femalesEvaluation of edonerpic maleate as a CRMP2 inhibitor for pain reliefBetulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channelsDefining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectantCdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain
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researcher ORCID ID = 0000-0003-4268-1206
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0000-0003-4268-1206