about
Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorptionHypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.2-Azetidinones as inhibitors of cholesterol absorption.2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.Iminoheterocycles as gamma-secretase modulators.Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.An enzymatic synthesis of glucuronides of azetidinone-based cholesterol absorption inhibitorsStructure-activity relationships of pyrroloquinazolines as thrombin receptor antagonistsHydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonistsTetrahydroisoquinolines as MCH-R1 antagonistsNovel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseasesSAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERGSynthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonistsCyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivoDesign and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicitySynthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonistsDesign and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonistsIdentification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexesTetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studiesA-ring modification of SCH 900229 and related chromene sulfone γ-secretase inhibitors
P50
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P50
description
researcher ORCID ID = 0000-0002-1444-7802
@en
wetenschapper
@nl
name
Duane A Burnett
@ast
Duane A Burnett
@en
Duane A Burnett
@es
Duane A Burnett
@nl
type
label
Duane A Burnett
@ast
Duane A Burnett
@en
Duane A Burnett
@es
Duane A Burnett
@nl
prefLabel
Duane A Burnett
@ast
Duane A Burnett
@en
Duane A Burnett
@es
Duane A Burnett
@nl
P1153
7102281808
P31
P496
0000-0002-1444-7802