about
A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptorDetermination of Pore-Lining Residues in the Hepatitis C Virus p7 ProteinMolecular Basis of Kainate Receptor Modulation by SodiumRapid and accurate prediction and scoring of water molecules in protein binding sitesThe role of flexibility and conformational selection in the binding promiscuity of PDZ domainsExploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesisBookshelf: a simple curation system for the storage of biomolecular simulation dataUsing the fragment molecular orbital method to investigate agonist-orexin-2 receptor interactionsPredictions of Ligand Selectivity from Absolute Binding Free Energy CalculationsStudy of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed MutagenesisBeyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Mutationmapper: a tool to aid the mapping of protein mutation data.Dynamics based alignment of proteins: an alternative approach to quantify dynamic similarityConformational preferences of a 14-residue fibrillogenic peptide from acetylcholinesteraseJGromacs: a Java package for analyzing protein simulations.Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors.Channel gating: twist to open.Glutamate receptors: desensitizing dimers.Potassium channels: structures, models, simulations.Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytesIon channel gating: insights via molecular simulations.GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster.Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides.Waterdock 2.0: Water placement prediction for Holo-structures with a pymol pluginAccurate calculation of the absolute free energy of binding for drug molecules.Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanismDistinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.A steroid in a lipid bilayer: localization, orientation, and energetics.Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pumpDistribution and dynamics of adamantanes in a lipid bilayerSelectivity and cooperativity of modulatory ions in a neurotransmitter receptorThe 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy.Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation.Towards understanding promiscuity in multidrug efflux pumps.Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.Homology modelling of human P-glycoprotein.The solvation structure of alprazolam.Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents.Guiding lead optimization with GPCR structure modeling and molecular dynamics.
P50
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P50
description
researcher ORCID ID = 0000-0001-5100-8836
@en
wetenschapper
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name
Philip C Biggin
@ast
Philip C Biggin
@en
Philip C Biggin
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Philip C Biggin
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Philip C Biggin
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Philip C Biggin
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Philip C Biggin
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Philip C Biggin
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altLabel
Philip Biggin
@en
prefLabel
Philip C Biggin
@ast
Philip C Biggin
@en
Philip C Biggin
@es
Philip C Biggin
@nl
P106
P1153
6603854881
P2456
P31
P496
0000-0001-5100-8836