Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis

Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis

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http://www.wikidata.org/entity/Q29031166
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012OX1 and OX2 orexin/hypocretin receptor pharmacogeneticsStructure and ligand-binding mechanism of the human OX1 and OX2 orexin receptorsUsing the fragment molecular orbital method to investigate agonist-orexin-2 receptor interactionsBeyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.Characterization of the dynamic events of GPCRs by automated computational simulations.Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis.Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies.Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics.Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery.The Human Orexin/Hypocretin Receptor Crystal Structures.Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.GPCR Homology Model Generation for Lead Optimization.Mapping histamine H4receptor–ligand binding modes
P2860

Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis

Item
http://www.wikidata.org/entity/Q29031166
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Study of Human Orexin-1 and -2 ...... and Site-Directed Mutagenesis
@ast
Study of Human Orexin-1 and -2 ...... and Site-Directed Mutagenesis
@en
type
label
Study of Human Orexin-1 and -2 ...... and Site-Directed Mutagenesis
@ast
Study of Human Orexin-1 and -2 ...... and Site-Directed Mutagenesis
@en
prefLabel
Study of Human Orexin-1 and -2 ...... and Site-Directed Mutagenesis
@ast
Study of Human Orexin-1 and -2 ...... and Site-Directed Mutagenesis
@en
P1433
P1476
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921
P3181
P356
P1433
P1476
Study of human Orexin-1 and -2 ...... and site-directed mutagenesis
@en
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921