about
PKM2, cancer metabolism, and the road ahead.Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibitionActivation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancerAspartate is an endogenous metabolic limitation for tumour growthYap regulates glucose utilization and sustains nucleotide synthesis to enable organ growthLack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarateMicroenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studiesQuantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availabilityEmerging Roles for Branched-Chain Amino Acid Metabolism in CancerA framework for examining how diet impacts tumour metabolismPostdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic CancerA Metabolomics Analysis of Adiposity and Advanced Prostate Cancer Risk in the Health Professionals Follow-Up StudyCellular redox state constrains serine synthesis and nucleotide production to impact cell proliferationCancer-associated mutations in human pyruvate kinase M2 impair enzyme activityIdentification of DHODH as a therapeutic target in small cell lung cancerReactive metabolite production is a targetable liability of glycolytic metabolism in lung cancerIncreased PHGDH expression promotes aberrant melanin accumulationDeoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance
P50
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P50
description
researcher ORCID ID = 0000-0002-6702-4192
@en
wetenschapper
@nl
name
Matthew G Vander Heiden
@ast
Matthew G Vander Heiden
@en
Matthew G Vander Heiden
@nl
type
label
Matthew G Vander Heiden
@ast
Matthew G Vander Heiden
@en
Matthew G Vander Heiden
@nl
prefLabel
Matthew G Vander Heiden
@ast
Matthew G Vander Heiden
@en
Matthew G Vander Heiden
@nl
P31
P496
0000-0002-6702-4192