about
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinaseDiscovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamilyDesign, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitorsPurified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2.Heat-stable inhibitor of translation in reticulocyte lysates.Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Escherichia coli-synthesized Ha-ras-encoded p21.Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli.Bacterial gene expression and biotechnology.Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.Apoptotic and cytostatic farnesyltransferase inhibitors have distinct pharmacology and efficacy profiles in tumor models.Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.Studies of the mechanism of bacteriophage T4 DNA encapsidation.Phase I pharmacokinetic and pharmacodynamic study of weekly 1-hour and 24-hour infusion BMS-214662, a farnesyltransferase inhibitor, in patients with advanced solid tumors.Effect of divalent metal ions and glycerol on the GTPase activity of H-ras proteins.Pyrrolopyridazine MEK inhibitors.Identification of polyphosphoinositide-specific phospholipase C and its resolution from phosphoinositide-specific phospholipase C from human platelet extract.Farnesylation of p21 Ras proteins in Xenopus oocytes.Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins.10'-Desmethoxystreptonigrin, a novel analog of streptonigrinA novel candidate for receptor-coupled phospholipase C purified from human plateletsA bacteriophage T4 DNA packaging related DNA-dependent ATPase-endonucleaseFarnesyl diphosphate-based inhibitors of Ras farnesyl protein transferaseDiscovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferaseContribution of Ras GTPase/MAP kinase and cytochrome P450 metabolites to deoxycorticosterone-salt-induced hypertension3-Imidazolylmethylaminophenylsulfonyltetrahydroquinolines, a novel series of farnesyltransferase inhibitors
P50
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P50
description
researcher ORCID ID = 0000-0002-1179-5529
@en
wetenschapper
@nl
name
Veeraswamy Manne
@ast
Veeraswamy Manne
@en
Veeraswamy Manne
@es
Veeraswamy Manne
@nl
type
label
Veeraswamy Manne
@ast
Veeraswamy Manne
@en
Veeraswamy Manne
@es
Veeraswamy Manne
@nl
prefLabel
Veeraswamy Manne
@ast
Veeraswamy Manne
@en
Veeraswamy Manne
@es
Veeraswamy Manne
@nl
P31
P496
0000-0002-1179-5529