Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
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Mechanism and regulation of eukaryotic protein synthesisMultidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifsGuanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3.Complex formation by positive and negative translational regulators of GCN4.Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiaeMutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.Activation of NF-kappaB by double-stranded RNA (dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programsComplementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor.HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae.The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.Inhibition of binding to initiation complexes of nascent reovirus mRNA by double-stranded RNA-dependent protein kinase.Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells.Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAsAmino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases.Formation of a translational inhibitor by interaction of phospholipid with the eukaryotic initiation factor 2.Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA.Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.Mechanism of activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid.Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.Regulation of cell proliferation and differentiation by interferons.Regulated cell death and adaptive stress responses.Initiation of protein synthesis in mammalian cellsCorrelation between the distribution of the reversing factor and eukaryotic initiation factor 2 in heme-deficient or double-stranded RNA-inhibited reticulocyte lysates.Functional heterogeneity of GEF-free initiation factor 2 purified from suckling and adult rat brain.Partial purification of a novel N-ethylmaleimide-activated translational inhibitor from adult rat brain.Inducers of erythroleukemic differentiation cause messenger RNAs that lack poly(A)-binding protein to accumulate in translationally inactive, salt-labile 80 S ribosomal complexes.Translational inhibition by eIF-2-phospholipid complex in mammalian cell-free systems.
P2860
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P2860
Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
1984年论文
@zh
1984年论文
@zh-cn
name
Mechanism of translational con ...... ukaryotic initiation factor 2.
@ast
Mechanism of translational con ...... ukaryotic initiation factor 2.
@en
type
label
Mechanism of translational con ...... ukaryotic initiation factor 2.
@ast
Mechanism of translational con ...... ukaryotic initiation factor 2.
@en
prefLabel
Mechanism of translational con ...... ukaryotic initiation factor 2.
@ast
Mechanism of translational con ...... ukaryotic initiation factor 2.
@en
P2860
P356
P1476
Mechanism of translational con ...... eukaryotic initiation factor 2
@en
P2093
P2860
P304
P356
10.1073/PNAS.81.2.352
P407
P577
1984-01-01T00:00:00Z