about
A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90Hsp90 orchestrates stress response signaling governing fungal drug resistanceAcquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistanceMapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitryThe Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistanceGlobal analysis of the evolution and mechanism of echinocandin resistance in Candida glabrataGenetic and genomic architecture of the evolution of resistance to antifungal drug combinationsFunctional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular StatesGlobal Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen AdaptationMapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular StressMetal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and MorphogenesisMultilocus genotyping indicates that the ability to invade the bloodstream is widespread among Candida albicans isolatesEvolution of drug resistance in experimental populations of Candida albicans.Population genomics of drug resistance in Candida albicans.Regulatory circuitry governing fungal development, drug resistance, and disease.Elucidating drug resistance in human fungal pathogens.Predicting the emergence of resistance to antifungal drugs.Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.Global analysis of fungal morphology exposes mechanisms of host cell escape.Dual action antifungal small molecule modulates multidrug efflux and TOR signalingSignaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation.The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferationStress, drugs, and evolution: the role of cellular signaling in fungal drug resistanceBeauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29.Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31.Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.Thermal control of microbial development and virulence: molecular mechanisms of microbial temperature sensing.Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence.Mechanisms of Antifungal Drug Resistance.Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies.Using combination therapy to thwart drug resistance.Candida albicans Is Resistant to Polyglutamine Aggregation and ToxicityLysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.The Hsp90 Chaperone Network Modulates Candida Virulence Traits.Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans.Molecular Evolution of Antifungal Drug Resistance.Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans.
P50
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P50
description
researcher ORCID ID = 0000-0001-5797-0110
@en
name
Leah E Cowen
@ast
Leah E Cowen
@en
Leah E Cowen
@es
Leah E Cowen
@nl
type
label
Leah E Cowen
@ast
Leah E Cowen
@en
Leah E Cowen
@es
Leah E Cowen
@nl
prefLabel
Leah E Cowen
@ast
Leah E Cowen
@en
Leah E Cowen
@es
Leah E Cowen
@nl
P108
P1153
7003498523
P31
P496
0000-0001-5797-0110