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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptorsAntibodies specifically targeting a locally misfolded region of tumor associated EGFRA new crystal form of human vascular adhesion protein 1The structure of vanin 1: a key enzyme linking metabolic disease and inflammationNotch ligand delta-like1: X-ray crystal structure and binding affinityLRIG1 extracellular domain: structure and function analysisStructural and functional characterisation of ferret interleukin-2Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptorTaking down the FLAG! How insect cell expression challenges an established tag-systemStructural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase.Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liver.New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells.Structure and function of the type 1 insulin-like growth factor receptor.Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.Direct involvement of the TEN domain at the active site of human telomeraseBlood-based protein biomarker panel for the detection of colorectal cancerDevelopment of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.Structural insights into ligand-induced activation of the insulin receptor.Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation.Incomplete target neutralization by the anti-cancer antibody rilotumumab.Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelledPositive and negative regulatory elements in the late lactation protein-A gene promoter from the tammar wallaby (Macropus eugenii).EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation.A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo.Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.UV induced responses of the human epidermal IGF system: impaired anti-apoptotic effects of IGF-I in HaCaT keratinocytes.Cloning and DNA sequence analysis of the cDNA for the common alpha-subunit of the ovine pituitary glycoprotein hormonesIdentification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor.CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.Identification of a liver-specific promoter for the ovine growth hormone receptor.Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.
P50
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P50
description
researcher ORCID ID = 0000-0003-3436-0066
@en
name
Timothy E Adams
@ast
Timothy E Adams
@en
Timothy E Adams
@nl
تيموثي إي آدامز
@ar
type
label
Timothy E Adams
@ast
Timothy E Adams
@en
Timothy E Adams
@nl
تيموثي إي آدامز
@ar
prefLabel
Timothy E Adams
@ast
Timothy E Adams
@en
Timothy E Adams
@nl
تيموثي إي آدامز
@ar
P31
P496
0000-0003-3436-0066