about
Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophySilencing of NHE-1 blunts the slow force response to myocardial stretchNovel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Reactive oxygen species partially mediate high dose angiotensin II-induced positive inotropic effect in cat ventricular myocytes.Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1.Role of autocrine/paracrine mechanisms in response to myocardial strain.The Anrep effect: 100 years later.Cardiac hypertrophy reduction in SHR by specific silencing of myocardial Na(+)/H(+) exchanger.Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility.Myocardial mineralocorticoid receptor activation by stretching and its functional consequences.Decreased activity of the Na+/H+ exchanger by phosphodiesterase 5A inhibition is attributed to an increase in protein phosphatase activity.Phosphodiesterase 5A inhibition decreases NHE-1 activity without altering steady state pH(i): role of phosphatases.Mineralocorticoid receptor activation is crucial in the signalling pathway leading to the Anrep effect.Nitric oxide and CaMKII: Critical steps in the cardiac contractile response To IGF-1 and swim training.Mitochondrial reactive oxygen species activate the slow force response to stretch in feline myocardium.Enalapril induces regression of cardiac hypertrophy and normalization of pHi regulatory mechanisms.The Anrep effect requires transactivation of the epidermal growth factor receptor.In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy.Endogenous endothelin 1 mediates angiotensin II-induced hypertrophy in electrically paced cardiac myocytes through EGFR transactivation, reactive oxygen species and NHE-1.Effects of antihypertensive therapy on cardiac sodium/hydrogen ion exchanger activity and hypertrophy in spontaneously hypertensive rats.Upregulation of myocardial Na+/H+ exchanger induced by chronic treatment with a selective inhibitor.Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels.Regression of isoproterenol-induced cardiac hypertrophy by Na+/H+ exchanger inhibition.Influence of Na+-independent Cl--HCO3- exchange on the slow force response to myocardial stretch.Endothelin isoforms and the response to myocardial stretch.Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart.Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action.Gender differences in cardiac left ventricular mass and function: Clinical and experimental observations.Involvement of AE3 isoform of Na(+)-independent Cl(-)/HCO(3)(-) exchanger in myocardial pH(i) recovery from intracellular alkalization.The signaling pathway for aldosterone-induced mitochondrial production of superoxide anion in the myocardium.The positive inotropic effect of angiotensin II: role of endothelin-1 and reactive oxygen species.Normalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition.Phosphodiesterase 5A inhibition induces Na+/H+ exchanger blockade and protection against myocardial infarction.Structural basis of differences in isoform-specific gating and lidocaine block between cardiac and skeletal muscle sodium channels.Endurance training in the spontaneously hypertensive rat: conversion of pathological into physiological cardiac hypertrophy.Silencing of sodium/hydrogen exchanger in the heart by direct injection of naked siRNA.[Angiotensin II-induced endothelin-1 release in cardiac myocytes].Physiological cardiac hypertrophy: critical role of AKT in the prevention of NHE-1 hyperactivity.
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description
Investigadora
@es
Researcher
@en
onderzoeker
@nl
name
Irene Lucía Ennis
@ast
Irene Lucía Ennis
@en
Irene Lucía Ennis
@es
Irene Lucía Ennis
@nl
type
label
Irene Lucía Ennis
@ast
Irene Lucía Ennis
@en
Irene Lucía Ennis
@es
Irene Lucía Ennis
@nl
altLabel
Irene L. Ennis
@en
Irene L. Ennis
@es
prefLabel
Irene Lucía Ennis
@ast
Irene Lucía Ennis
@en
Irene Lucía Ennis
@es
Irene Lucía Ennis
@nl
P106
P1960
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