about
P688
Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania majorAn unusual type IB topoisomerase from African trypanosomes.DNA topoisomerase I from parasitic protozoa: a potential target for chemotherapy.Targeting atypical trypanosomatid DNA topoisomerase I.Characterizing the bi-subunit type IB DNA topoisomerase of Leishmania parasites; a novel scenario for drug intervention in trypanosomatids.Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance.An insight into the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani.'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani.RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential.N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit.The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase.Amino acids 39-456 of the large subunit and 210-262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania.Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani.
P921
Q33305441-F1AD91E0-687E-4384-A788-36D9E05D1B77Q33350046-75E3E60E-55B7-4850-9D42-EF22955CF891Q35146022-2662AF6E-A72F-4F07-AE55-9ABC1DDC1C29Q36498761-B7DEC9D8-3D89-40E4-90E0-D883AD3DBF57Q36538774-9D810807-47DE-44E6-BE62-84EE85C4848AQ37320216-F488C2BA-C718-4057-B5CE-18EE1A237868Q38288946-CD7CFB95-8758-4652-A2AC-49F35E6F71F0Q38292658-9DBFB54A-0BEA-4DCA-A355-6FF0D44BF1F5Q40106055-67CB0B5D-CAE5-4E45-9A7D-34F2293E28EBQ43504142-81F6C829-D726-4621-A8AF-7AEB49906109Q45265133-8FADF8FE-D832-40EB-A4F7-CC26BBD21ECDQ46884181-4C6851F4-95A8-4926-94C9-3790B2C90711Q46959432-699F59ED-2228-4325-AE73-123CB11D0CB8Q46977687-77090A1E-40F8-4EF8-9057-F603754521D2
P921
description
parasital protein found in Lei ...... M2904, encoded by LbrM.20.3020
@en
proteïne in DNA topoisomerase IB, large subunit
@nl
name
DNA topoisomerase IB, large subunit
@en
type
label
DNA topoisomerase IB, large subunit
@en
altLabel
LbrM20_V2.3020
@en
prefLabel
DNA topoisomerase IB, large subunit
@en
P681
P352
P279
P31
P3382
LbrM.20.3020:mRNA