An unusual type IB topoisomerase from African trypanosomes.
about
Characterization of the DNA-binding domain and identification of the active site residue in the 'Gyr A' half of Leishmania donovani topoisomerase IIActivity of Indenoisoquinolines against African TrypanosomesDeletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania majorProtein functional links in Trypanosoma brucei, identified by gene fusion analysis.Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.Gene fusion analysis in the battle against the African endemic sleeping sicknessA lupane-triterpene isolated from Combretum leprosum Mart. fruit extracts that interferes with the intracellular development of Leishmania (L.) amazonensis in vitro.The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells.Novel antitrypanosomal agents.Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis.2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovaniTopoisomerases of kinetoplastid parasites: why so fascinating?A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB TopoisomeraseThe double-edged sword in pathogenic trypanosomatids: the pivotal role of mitochondria in oxidative stress and bioenergeticsTrypanosomatids topoisomerase re-visited. New structural findings and role in drug discoveryEfficacy of a Binuclear Cyclopalladated Compound Therapy for Cutaneous Leishmaniasis in the Murine Model of Infection with Leishmania amazonensis and Its Inhibitory Effect on Topoisomerase 1B.'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani.Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani.N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit.The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase.DNA topoisomerases in apicomplexan parasites: promising targets for drug discovery
P2860
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P2860
An unusual type IB topoisomerase from African trypanosomes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
An unusual type IB topoisomerase from African trypanosomes.
@ast
An unusual type IB topoisomerase from African trypanosomes.
@en
type
label
An unusual type IB topoisomerase from African trypanosomes.
@ast
An unusual type IB topoisomerase from African trypanosomes.
@en
prefLabel
An unusual type IB topoisomerase from African trypanosomes.
@ast
An unusual type IB topoisomerase from African trypanosomes.
@en
P2093
P2860
P921
P356
P1476
An unusual type IB topoisomerase from African trypanosomes.
@en
P2093
Annette L Bodley
Asit K Chakraborty
Christian Burri
Theresa A Shapiro
P2860
P304
P356
10.1073/PNAS.1330762100
P407
P577
2003-06-16T00:00:00Z