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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesThe GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathwayReceptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signalingInterferons at age 50: past, current and future impact on biomedicineGART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16High efficiency cell-specific targeting of cytokine activityBehavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background.The type I interferon receptor: structure, function, and evolution of a family business.Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression.Differential activity of type I interferon subtypes for dendritic cell differentiationHuman intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.IFNα signaling through PKC-θ is essential for antitumor NK cell functionAssessment of mTOR-Dependent Translational Regulation of Interferon Stimulated GenesNegative regulation of type I interferon signaling: facts and mechanisms.Performing quantitative reverse-transcribed polymerase chain reaction experiments.Receptor density is key to the alpha2/beta interferon differential activities.High efficiency targeting of IFN-α activity: possible applications in fighting tumours and infections.IFNA2: The prototypic human alpha interferon.Functional cartography of the ectodomain of the type I interferon receptor subunit ifnar1.Alpha and beta interferons and their receptor and their friends and relations.Receptor dynamics of closely related ligands: "fast' and "slow' interferons.Baseline sensitivity of T cells to alpha-IFN correlates with sustained virological response to IFN-based triple therapy in HCV infection.Murine tumor cells expressing the gene for the human interferon alpha beta receptor elicit antibodies in syngeneic mice to the active form of the receptor.Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.Differential receptor subunit affinities of type I interferons govern differential signal activation.Self-controlled monofunctionalization of quantum dots for multiplexed protein tracking in live cells.The receptor interaction region of Tyk2 contains a motif required for its nuclear localization.Biological activities and receptor binding of two human recombinant interferons and their hybrids.Type I interferons: expression and signalization.Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment.Signal Propagation in Sensing and Reciprocating Cellular Systems with Spatial and Structural Heterogeneity.Differential responsiveness to IFN-alpha and IFN-beta of human mature DC through modulation of IFNAR expression.Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21USP18 establishes the transcriptional and anti-proliferative interferon α/β differentialDifferences in Activity between α and β Type I Interferons Explored by Mutational AnalysisHydrophobic cluster analysis reveals duplication in the external structure of human alpha-interferon receptor and homology with gamma-interferon receptor external domain
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Gilles Uzé
@ast
Gilles Uzé
@en
Gilles Uzé
@es
Gilles Uzé
@nl
type
label
Gilles Uzé
@ast
Gilles Uzé
@en
Gilles Uzé
@es
Gilles Uzé
@nl
prefLabel
Gilles Uzé
@ast
Gilles Uzé
@en
Gilles Uzé
@es
Gilles Uzé
@nl
P106
P31
P496
0000-0002-4150-5772