about
Bioactive components in fish venomsδ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snailsSolution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonanceConotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structureTwo new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporterA new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activityIsolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequenceA Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating DomainChemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophoresThree-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channelsThree-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicityD-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypusSelective spider toxins reveal a role for the Nav1.1 channel in mechanical painAncient Venom Systems: A Review on Cnidaria ToxinsEvolution of separate predation- and defence-evoked venoms in carnivorous cone snailsPharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Rapid sensitive analysis of cysteine rich peptide venom components.Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels.Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins.Accelerated chemical synthesis of peptides and small proteinsSystematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies.Cone snail venomics: from novel biology to novel therapeutics.Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity.Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.Venomics: a new paradigm for natural products-based drug discovery.Cysteine-rich mini-proteins in human biology.Discovery, synthesis, and structure-activity relationships of conotoxins.Privileged frameworks from snake venom.The role of defensive ecological interactions in the evolution of conotoxins.α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors.Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors.Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose.
P50
Q27011908-FE9711F4-9956-4871-852F-E12D86AD2E86Q27329762-0C454380-2458-47A5-910A-44F5F939756AQ27618965-CD19EE0E-14BB-4D7C-8CE4-FB6D8C8A82BAQ27625415-2A8397D1-DE84-4D84-BFF8-DD2D4113B325Q27634633-9B9E0156-7F40-4843-A66E-B1E4ED1E7C2DQ27639764-C5B88E84-A8D7-424B-990E-EB0D3AB20107Q27639921-F8ACC2D3-8F36-43BF-9282-27921E5B6ED5Q27681733-4B67A223-12EF-4A37-95EE-A720712F2582Q27684283-CA8E4169-CC9A-4BE7-904E-59867AB8B8A1Q27695723-7BB1B3A3-9C9E-4F6C-A00D-B264E9048D4FQ27733152-7C78171A-8889-44D8-B300-B1A1D1C60E13Q27766129-A2D043B0-3807-46D5-9F86-5A15C3792C2EQ28215680-DB5CAF6F-1FA8-4F94-AB57-C1DCF517934FQ28594552-FC76C0B4-DDE4-400B-8217-AF87C572D267Q28647678-E0838BCF-4C19-48A8-9EC7-F7C6AAD9357AQ30575296-4D9C1F4D-2B72-479F-B039-C71450172AF3Q30835612-C61CBC58-7BD7-44E2-941E-9389FCED4B85Q33432520-8914F820-5717-4525-ACCF-D203ADD635C1Q33842774-894CDB26-603A-4B87-AD80-32D8CF90D83AQ33991060-FA11A13C-5B1B-4801-B135-6E0F4C2477B3Q34720150-1BC37106-8C52-4024-AB77-DD7D097C6848Q34983403-2E845D91-1492-406C-8FA0-95533D23FD44Q35019115-E20FB2FA-E879-4FF0-B63E-002F5EB44C80Q35432836-D74FE9F0-6E6A-4DD1-A366-455AA7C8A47EQ35684927-B343A338-7E6B-4F61-8EB0-E80BB0D40B6FQ35918284-DD1C9B46-253E-42FE-98BD-262B5821D97EQ36941125-7F569ECC-54D6-42F4-87BB-26658C2BA8A5Q37348886-6B696CCF-98F1-4921-87FC-54801C4121F5Q37369881-DA604804-BDE8-4F8E-9644-3911ADB5999FQ37389019-2E813C00-E80B-4A01-AD29-9D55D6B0023EQ37618313-AF90F754-ACE4-4518-92A2-7FB6167EA0C5Q37697029-067906AD-8035-42D1-923C-E387610E4216Q38029087-C431E653-1786-44E0-BFD7-C3F1FC87C5BAQ38203598-FE34DE39-299B-4E95-AC92-473B5BF7B4F1Q38360688-96061E08-7F90-44DA-8B87-929BFF1D3221Q38816124-78F233FA-CFC3-42B2-86DB-89B72367E681Q38913524-197BEFE6-4559-41C5-9E0D-9F5CDAE1A067Q39042143-F7E3D1D6-603B-4840-8069-48DB87FDBAF2Q39113921-0F3D669C-0DFE-412F-A8D6-ADAB509F1267Q39115929-A3EE4EBE-8286-42C2-9039-BBEE1018716A
P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Paul F Alewood
@ast
Paul F Alewood
@en
Paul F Alewood
@es
Paul F Alewood
@nl
type
label
Paul F Alewood
@ast
Paul F Alewood
@en
Paul F Alewood
@es
Paul F Alewood
@nl
prefLabel
Paul F Alewood
@ast
Paul F Alewood
@en
Paul F Alewood
@es
Paul F Alewood
@nl
P106
P31
P496
0000-0001-7454-6522