Discovery, synthesis, and structure-activity relationships of conotoxins.
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Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel InhibitionBioactive Mimetics of Conotoxins and other Venom PeptidesIn the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compoundsResidues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRsArtificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.Alanine scan of α-conotoxin RegIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist.Cone snail venomics: from novel biology to novel therapeutics.Inhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails.Bioinformatics-Aided VenomicsA novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype.Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus.Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters.Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom.In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii.High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method.Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.Converting disulfide bridges in native peptides to stable methylene thioacetals.Structure-Activity Relationships of Insect Defensins.Recent Advances in Conotoxin Classification by Using Machine Learning Methods.Advances in venomics.A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics.The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn't.Computational exploration of a protein receptor binding space with student proposed peptide ligands.Easy and rapid binding assay for functional analysis of disulfide-containing peptides by a pull-down method using a puromycin-linker and a cell-free translation system.Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery.Molecular Engineering of Conus Peptides as Therapeutic Leads.Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom.Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis.G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides.A novel α-conopeptide Eu1.6 inhibits N-type (CaV2.2) calcium channels and exhibits potent analgesic activity.Disulfide Bond Mimetics: Strategies and Challenges.Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer.Chemistry and Enzymology of Disulfide Cross-Linking in Proteins.
P2860
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P2860
Discovery, synthesis, and structure-activity relationships of conotoxins.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Discovery, synthesis, and structure-activity relationships of conotoxins.
@en
type
label
Discovery, synthesis, and structure-activity relationships of conotoxins.
@en
prefLabel
Discovery, synthesis, and structure-activity relationships of conotoxins.
@en
P50
P356
P1433
P1476
Discovery, synthesis, and structure-activity relationships of conotoxins
@en
P2093
Kalyana B Akondi
P304
P356
10.1021/CR400401E
P577
2014-04-10T00:00:00Z