about
A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surfaceThe farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c.Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces.Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.Bivalent inhibitors for disrupting protein surface-substrate interactions and for dual inhibition of protein prenyltransferases.Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanoneTransannular proton transfer in the cyclization of geranylgeranyl diphosphate to fusicoccadiene, a biosynthetic intermediate of fusicoccinsAntimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthaseCopper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide ConjugatesStructural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic ActivityA Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-RafDipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Junko Ohkanda
@ast
Junko Ohkanda
@en
Junko Ohkanda
@es
Junko Ohkanda
@nl
type
label
Junko Ohkanda
@ast
Junko Ohkanda
@en
Junko Ohkanda
@es
Junko Ohkanda
@nl
prefLabel
Junko Ohkanda
@ast
Junko Ohkanda
@en
Junko Ohkanda
@es
Junko Ohkanda
@nl
P108
P106
P1153
6701848986
P31
P496
0000-0001-9663-5104