Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growthHDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCsSiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsTargeting protein prenylation for cancer therapyA novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells(--)-Xanthatin selectively induces GADD45γ and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells.Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/NF-κB pathway and MMP-2 production by targeting RhoB activationExpression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development.Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?Activation of the RhoB signaling pathway by thyroid hormone receptor β in thyroid cancer cellsRhoB upregulation leads to either apoptosis or cytostasis through differential target selection.Regulation of cholesterol biosynthesis and cancer signalingPhase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells.A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS‑mediated c‑Abl/p38 MAPK signaling.Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells.A distinct role of RhoB in gastric cancer suppression.Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.Statins Modulate Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 in Human Hepatic Myofibroblasts.Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification.RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha.Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.RhoB: Team Oncogene or Team Tumor Suppressor?Liposomal trichostatin A: therapeutic potential in hormone-dependent and -independent breast cancer xenograft models.NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells.Functionalized MoS Nanosheets as Multi-Gene Delivery Vehicles for Pancreatic Cancer Therapy
P2860
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P2860
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Farnesyltransferase and gerany ...... tylation of the RhoB promoter.
@en
Farnesyltransferase and gerany ...... tylation of the RhoB promoter.
@nl
type
label
Farnesyltransferase and gerany ...... tylation of the RhoB promoter.
@en
Farnesyltransferase and gerany ...... tylation of the RhoB promoter.
@nl
prefLabel
Farnesyltransferase and gerany ...... tylation of the RhoB promoter.
@en
Farnesyltransferase and gerany ...... tylation of the RhoB promoter.
@nl
P2093
P2860
P356
P1433
P1476
Farnesyltransferase and gerany ...... etylation of the RhoB promoter
@en
P2093
Bizouarn F
Blaskovich MA
Chellappan S
Delarue FL
Hamilton AD
P2860
P2888
P304
P356
10.1038/SJ.ONC.1209819
P407
P577
2006-08-14T00:00:00Z