about
Roles of the nucleolus in the CAG RNA-mediated toxicityRNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosisFE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowthIdentification and characterization of the gene for Drosophila L3 ribosomal protein.BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells.Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1.Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.Identification and characterization of the gene for Drosophila S20 ribosomal protein.The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity.A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular DiseasesDegradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats.Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.Black tea theaflavins extend the lifespan of fruit flies.Protective role of Engrailed in a Drosophila model of Huntington's disease.Expression of expanded CAG transcripts triggers nucleolar stress in Huntington's disease.Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases.Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery.Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor.Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model.Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster.Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting.Mechanism for the Cellular Uptake of Targeted Gold Nanorods of Defined Aspect Ratios.Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.Fly-ing from genes to drugs.Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in Drosophila.Apple polyphenols extend the mean lifespan of Drosophila melanogaster.Blueberry extract prolongs lifespan of Drosophila melanogaster.Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal StressEfficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Chan, H.Y.E.
@ast
Chan, H.Y.E.
@en
Chan, H.Y.E.
@nl
type
label
Chan, H.Y.E.
@ast
Chan, H.Y.E.
@en
Chan, H.Y.E.
@nl
prefLabel
Chan, H.Y.E.
@ast
Chan, H.Y.E.
@en
Chan, H.Y.E.
@nl
P1053
A-9478-2011
P106
P2798
P31
P496
0000-0003-4307-474X