about
Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpEHSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasomeThe ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor familyLocalization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiencyThe cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutantsMutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membraneDisruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebratesIsolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retinaDeficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanismTopography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.Assignment of the neuronal cochaperone, HSJ1, to human chromosome bands 2q32-->q34 between D2S295 and D2S339 by in situ hybridization and somatic cell and radiation hybrids.Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.Unfolding retinal dystrophies: a role for molecular chaperones?A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix SaguenayCytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK.Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1βCan faulty antennae increase adiposity? The link between cilia proteins and obesity.The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease.Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control.The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.Primary cilia: a link between hormone signalling and endocrine-related cancers?Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface.The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.Organization on the plasma membrane of the retinitis pigmentosa protein RP2: investigation of association with detergent-resistant membranes and polarized sortingInterleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation.Assay and functional analysis of the ARL3 effector RP2 involved in X-linked retinitis pigmentosa.Heat shock induces rapid resorption of primary ciliaThe binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.Delineation of the plasma membrane targeting domain of the X-linked retinitis pigmentosa protein RP2.Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking.Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
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description
investigador
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researcher
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wetenschapper
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Paul Chapple
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Paul Chapple
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Paul Chapple
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Paul Chapple
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Paul Chapple
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Paul Chapple
@nl
prefLabel
Paul Chapple
@ast
Paul Chapple
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Paul Chapple
@nl
P106
P31
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0000-0003-1876-1505