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Guidelines for the use and interpretation of assays for monitoring autophagyIntracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion diseaseUltra-sensitive detection of prion protein fibrils by flow cytometry in blood from cattle affected with bovine spongiform encephalopathyCritical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion proteinAnalysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion proteinAptamers against prion proteins and prions.Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.In vitro and in vivo neurotoxicity of prion protein oligomers.Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition.A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasisAssessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line.Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion proteinModulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake.Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cellsMolecular basis of cerebral neurodegeneration in prion diseases.Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.Prion strains depend on different endocytic routes for productive infection.LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer's Disease.Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpainConditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.Dynamic interactions of Sup35p and PrP prion protein domains modulate aggregate nucleation and seeding.Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro.Prion protein/protein interactions: fusion with yeast Sup35p-NM modulates cytosolic PrP aggregation in mammalian cells.The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.The anticancer drug imatinib induces cellular autophagy.Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.The prion protein requires cholesterol for cell surface localization.Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform encephalopathy and scrapie infections.The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.Neurotrophic factors: ready to go?Stability and conformational properties of doppel, a prion-like protein, and its single-disulphide mutant.Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.The octarepeat region of prion protein, but not the TM1 domain, is important for the antioxidant effect of prion protein.Individuals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection: high percentage of carriers of hepatitis B and C virus.GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.Detection of PrP(Sc) in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy.
P50
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P50
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Forscher
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Hermann M Schätzl
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Hermann M Schätzl
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Hermann M Schätzl
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Hermann M Schätzl
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Hermann M Schätzl
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H M Schätzl
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Hermann M Schätzl
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Hermann M Schätzl
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Hermann M Schätzl
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Hermann M Schätzl
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P106
P1153
7004486352
P31
P496
0000-0003-4972-8740