about
CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cellsFitness of Leishmania donovani parasites resistant to drug combinationsBis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy.LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of LeishmaniaHigh-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.A new ABC half-transporter in Leishmania major is involved in resistance to antimony.Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein gene.Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.4-amino bis-pyridinium derivatives as novel antileishmanial agents.Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulatorThe LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance.The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania majorTafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosisDecreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola.Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols.Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter.Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi.Functional role of highly-conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase.SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunitIdentification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening
P50
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P50
description
researcher
@en
name
S Castanys
@en
S Castanys
@nl
type
label
S Castanys
@en
S Castanys
@nl
prefLabel
S Castanys
@en
S Castanys
@nl
P106
P31
P496
0000-0002-3460-844X