about
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigsHaptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug developmentInduction and antimicrobial activity of platelet basic protein derivatives in human monocytes.Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages.Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig modelModeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor.Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.[Not a tropical, but a non the less exotic fever].Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage.Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex.Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case.Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes.Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome.Clearance and control mechanisms of hemoglobin from cradle to grave.Inhibition of meningitis-associated neutrophil apoptosis by TNF-α depends on functional PI3-kinase in monocytes.CME: Das Schweizer Fallpauschalensystem.Proteinase-activated receptors induce nonoxidative, antimicrobial peptides and increased antimicrobial activity in human mononuclear phagocytes.Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics.[Behçet disease].Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modificationInduction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids.Assignment of the CD163 antigen (CD163) to mouse chromosome 6 band F2 by radiation hybrid mappingExpression of the hemoglobin scavenger receptor (CD163/HbSR) as immunophenotypic marker of monocytic lineage in acute myeloid leukemiaThe macrophage hemoglobin scavenger receptor (CD163) as a genetically determined disease modifying pathway in atherosclerosisComment to: F. M. Nackhoul et al. (2001) Haptoglobin phenotype and diabetic nephropathy. Diabetologia 44: 602-604Regulated expression of platelet factor 4 in human monocytes--role of PARs as a quantitatively important monocyte activation pathwayExpression of CD163 on human histiocytic cells is different in tuberculosis-induced and schistosomiasis-induced granulomasExtracellular hemoglobin polarizes the macrophage proteome toward Hb-clearance, enhanced antioxidant capacity and suppressed HLA class 2 expressionQuantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin[Löfgren syndrome - the acute form of sarcoidosis][CME. Biologics in vasculitis][Therapy of anaphylaxis]
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description
researcher
@en
name
D J Schaer
@en
D J Schaer
@nl
type
label
D J Schaer
@en
D J Schaer
@nl
prefLabel
D J Schaer
@en
D J Schaer
@nl
P106
P31
P496
0000-0002-6468-4013