about
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeatEnergetics of a hydrogen bond (charged and neutral) and of a cation-pi interaction in apoflavodoxinCommon conformational changes in flavodoxins induced by FMN and anion binding: the structure of Helicobacter pylori apoflavodoxinDiscovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infectionDesign and structure of an equilibrium protein folding intermediate: a hint into dynamical regions of proteinsStructural and mechanistic basis of the interaction between a pharmacological chaperone and human phenylalanine hydroxylaseThe closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosomeTherapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imigluceraseAllosteric inhibitors of the NS3 protease from the hepatitis C virusInhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel InhibitorsStreptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug TargetA double-deletion method to quantifying incremental binding energies in proteins from experiment: example of a destabilizing hydrogen bonding pair.Energetics of aliphatic deletions in protein coresComputational diagnosis of protein conformational diseases: short molecular dynamics simulations reveal a fast unfolding of r-LDL mutants that cause familial hypercholesterolemia.Design of ligand binding to an engineered protein cavity using virtual screening and thermal up-shift evaluation.VSDMIP: virtual screening data management on an integrated platform.ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble.Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening.Defining the nature of thermal intermediate in 3 state folding proteins: apoflavodoxin, a study case.Discovery of novel inhibitors of amyloid β-peptide 1-42 aggregation.Sequence-specific solvent accessibilities of protein residues in unfolded protein ensembles.Intradomain Confinement of Disulfides in the Folding of Two Consecutive Modules of the LDL ReceptorBenzbromarone, Quercetin, and Folic Acid Inhibit Amylin AggregationHigh-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors.Flavodoxins: sequence, folding, binding, function and beyond.Antimicrobial susceptibility and resistance patterns among Helicobacter pylori strains from The Gambia, West Africa.The flavodoxin from Helicobacter pylori: structural determinants of thermostability and FMN cofactor binding.Protein-cation interactions: structural and thermodynamic aspects.The stability of 2-state, 3-state and more-state proteins from simple spectroscopic techniques... plus the structure of the equilibrium intermediates at the same time.Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.In vivo reconstitution of a homodimeric cytochrome b559 like structure: The role of the N-terminus α-subunit from Synechocystis sp. PCC 6803.Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate.Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases.The FurA regulon in Anabaena sp. PCC 7120: in silico prediction and experimental validation of novel target genes.Predicting stabilizing mutations in proteins using Poisson-Boltzmann based models: study of unfolded state ensemble models and development of a successful binary classifier based on residue interaction energies.Molten globule and native state ensemble of Helicobacter pylori flavodoxin: can crowding, osmolytes or cofactors stabilize the native conformation relative to the molten globule?An extensive thermodynamic characterization of the dimerization domain of the HIV-1 capsid protein.PrionScan: an online database of predicted prion domains in complete proteomes.Rational stabilization of complex proteins: a divide and combine approach.A comparative study of the thermal stability of plastocyanin, cytochrome c(6) and Photosystem I in thermophilic and mesophilic cyanobacteria.
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
J Sancho
@en
J Sancho
@nl
type
label
J Sancho
@en
J Sancho
@nl
prefLabel
J Sancho
@en
J Sancho
@nl
P106
P31
P496
0000-0002-2879-9200