about
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamateAn NBD Derivative of the Selective Rat Toxicant Norbormide as a New Probe for Living Cell ImagingMarine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulationTheonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor.HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes.Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling.Dissociation of intestinal and hepatic activities of FXR and LXRα supports metabolic effects of terminal ileum interposition in rodents.Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines.Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata.Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice.Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor.New tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei.Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei.Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination.Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors.Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.An intracellular adrenomedullin system reduces IL-6 release via a NF-kB-mediated, cAMP-independent transcriptional mechanism in rat thymic epithelial cells.Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists.Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1)4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunityLive applications of norbormide-based fluorescent probes in Drosophila melanogasterRitonavir-induced lipoatrophy and dyslipidaemia is reversed by the anti-inflammatory drug leflunomide in a PPAR-γ-dependent mannerDiethylstilbestrol-scaffold-based pregnane X receptor modulatorsDopamine-mediated immunomodulation affects choroid plexus function
P50
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P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Claudio D'Amore
@en
Claudio D'Amore
@nl
type
label
Claudio D'Amore
@en
Claudio D'Amore
@nl
prefLabel
Claudio D'Amore
@en
Claudio D'Amore
@nl
P31
P496
0000-0001-9217-9404