about
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models.Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk regionLoss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoEActive poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model
P50
description
investigador
@es
researcher
@en
wetenschapper
@nl
name
Samira Parhizkar
@en
Samira Parhizkar
@nl
type
label
Samira Parhizkar
@en
Samira Parhizkar
@nl
prefLabel
Samira Parhizkar
@en
Samira Parhizkar
@nl
P31
P496
0000-0001-5807-190X