about
Targeting IRE1 with small molecules counteracts progression of atherosclerosis.Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.Multiple selection filters ensure accurate tail-anchored membrane protein targeting.Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe.An unfolded protein-induced conformational switch activates mammalian IRE1.Development of a stress response therapy targeting aggressive prostate cancer.Engineering ER-stress dependent non-conventional mRNA splicing.The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein responsetRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decayCeapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tetherStructure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing moleculeActivation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndromeeIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress responseRibosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cellsQuantitative microscopy reveals dynamics and fate of clustered IRE1αDisruption of IRE1α through its kinase domain attenuates multiple myelomaMisfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stressStructure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extractionThe integrated stress response: From mechanism to diseaseGenotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
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P50
description
researcher (ORCID 0000-0002-6849-708X)
@en
wetenschapper
@nl
name
Peter Walter
@en
Peter Walter
@nl
type
label
Peter Walter
@en
Peter Walter
@nl
prefLabel
Peter Walter
@en
Peter Walter
@nl
P31
P496
0000-0002-6849-708X