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Q28506217-AF359AB6-C3E8-4C85-8A27-77D8276A165F
Q28506217-AF359AB6-C3E8-4C85-8A27-77D8276A165F
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Statement
http://www.wikidata.org/entity/statement/Q28506217-AF359AB6-C3E8-4C85-8A27-77D8276A165F
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter
P2860
Q28506217-AF359AB6-C3E8-4C85-8A27-77D8276A165F
BestRank
Statement
http://www.wikidata.org/entity/statement/Q28506217-AF359AB6-C3E8-4C85-8A27-77D8276A165F
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wasDerivedFrom
aec732870d0821eeffab27519dd3139fd742cd8d
P2860
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.