ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
about
Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer proteinInhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytesThe interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipidsLXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporterIdentification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factorsAlpha1-syntrophin modulates turnover of ABCA1.7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractHuman immunodeficiency virus impairs reverse cholesterol transport from macrophages.Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null miceA novel model of cholesterol efflux from lipid-loaded cellsLipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-IMutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexinTNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells.Mipu1 overexpression protects macrophages from oxLDL-induced foam cell formation and cell apoptosisA PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.Consequences of cellular cholesterol accumulation: basic concepts and physiological implicationsRIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages.ABCA1 and atherosclerosis.Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport.The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegenerationLentiviral transduction of apoAI into hematopoietic progenitor cells and macrophages: applications to cell therapy of atherosclerosis.Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis.Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.Cellular cholesterol regulates ubiquitination and degradation of the cholesterol export proteins ABCA1 and ABCG1Lipid outward translocation by ABC proteins.ABC proteins protect the human body and maintain optimal health.Function and regulation of ABCA1--membrane meso-domain organization and reorganization.Molecular biology of atherosclerosis.Oxysterols trigger ABCA1-mediated basolateral surfactant efflux.Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages.Lipid efflux in human and mouse macrophagic cells: evidence for differential regulation of phospholipid and cholesterol efflux.Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly.Glutamate enhances the surface distribution and release of Munc18 in cerebral cortical neuronsCritical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages.Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies.Association between the rs1805081 polymorphism of Niemann-Pick type C1 gene and cardiovascular disease in a sample of an Iranian population.Mitochondrial (dys)function and regulation of macrophage cholesterol efflux.
P2860
Q24535065-0C9FED6D-0BAA-42BA-AC41-50E17CBA51FBQ24648243-6A9BCDFD-EDCE-4ACB-BF31-E7AE1D654DD7Q27025329-018FF8EA-C832-4178-88BF-FB8C121A1938Q28245597-4EC6D71E-26E7-4648-83FA-9437B02E79AFQ28506217-AF359AB6-C3E8-4C85-8A27-77D8276A165FQ28593207-150960B0-83FF-41C0-82BD-1164B3D258B1Q33196798-C865B92C-5595-4D7E-88D9-480C6420B3DDQ33212396-C1A30A1E-846B-4C07-8D4B-A454DBDBB575Q33262244-F42CB7CE-4792-4433-ACCB-CECEAF807CC6Q33548671-3CEE3098-AA70-4FE6-A1A9-56C66BE1052AQ33577644-B96896D4-D692-4FBD-89EC-86DB872F254EQ34128528-B812DE7A-1EEE-48EC-951C-9B80AF0A3FEDQ34146122-A0EE704D-B58F-40E5-A757-F8805973FF13Q34355599-3A3C4E93-7FBE-4AC0-958F-1E8398C63152Q34480157-139D0128-8748-4143-BD58-6DD1496A7E83Q34589988-18644D19-0C51-46CF-AC25-94EFC48C05B0Q34827947-B0BB0B5A-04C9-479C-9C23-F27BE9A0DDADQ34949033-EAA20914-01FD-4499-8CE9-D97FA9BDC715Q34995879-D5801122-DEF2-4F24-ABE6-6E1766DAA7B9Q36192289-68D6EF5A-94E5-4B1A-B351-748B63008535Q36302734-02C95217-DF35-459B-9FCF-A554DE638D6BQ37017266-6DCF99CC-E16A-49DD-8B23-827EFF0688E1Q37348110-474ED05B-D775-4173-971E-17F11944DDFAQ37348324-CFEC3037-00EF-4F20-87AF-7A009A3FC847Q37382165-D822A69D-FE60-412B-B5CC-9ED93E66A9DDQ37635789-AE8AD957-749E-43E3-8A4C-135633516FB4Q37735992-26D3B0AB-9B40-40FC-8186-8E70662EA52AQ37851290-78807281-D197-444B-AC90-5FC36963F9E2Q37873571-75D0C445-D7FF-4009-944C-21E1149F9569Q38125279-D0E98A5E-9AF6-49F8-BF16-0C11EACF9ABFQ38343286-22B03822-2F04-44D0-B1B6-8426DE219C28Q39228850-3D94480F-3C09-4F74-AA6D-7CAF075ECFCAQ40402179-5C721796-EBFB-4882-BF4A-5BE981A5B086Q40608592-68D68938-D635-4E43-ABF7-CD96D301C210Q40638196-14559793-DD6B-44A4-9A4B-C3F0EA787BDDQ41351622-44B9614E-40B7-441A-995C-0360168F9199Q41935008-7C832550-3FA4-4F67-8208-76915B4C1C36Q42023940-E7F155F8-0740-40EA-94B6-C5340325C3F7Q42177398-3DEDE8CE-E025-4F77-8235-EEEAE2AE3141Q43849671-B0473BCB-3FD5-4102-8516-9BB13524F280
P2860
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
ABCA1-mediated cholesterol eff ...... requiring full NPC1 activity.
@en
type
label
ABCA1-mediated cholesterol eff ...... requiring full NPC1 activity.
@en
prefLabel
ABCA1-mediated cholesterol eff ...... requiring full NPC1 activity.
@en
P2860
P356
P1476
ABCA1-mediated cholesterol eff ...... requiring full NPC1 activity.
@en
P2093
P2860
P304
43271-43280
P356
10.1074/JBC.M207532200
P407
P577
2002-09-04T00:00:00Z