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Q33944673-F9938F85-3ADC-4710-A293-C932A98EAE94
Q33944673-F9938F85-3ADC-4710-A293-C932A98EAE94
BestRank
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http://www.wikidata.org/entity/statement/Q33944673-F9938F85-3ADC-4710-A293-C932A98EAE94
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
P2860
Q33944673-F9938F85-3ADC-4710-A293-C932A98EAE94
BestRank
Statement
http://www.wikidata.org/entity/statement/Q33944673-F9938F85-3ADC-4710-A293-C932A98EAE94
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wasDerivedFrom
6c9c0340e056bfe93bfc818b4bc4ec5379bf307a
P2860
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.