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Q34521260-1D564C22-09F0-4409-B035-386CFBA0A607
Q34521260-1D564C22-09F0-4409-B035-386CFBA0A607
BestRank
Statement
http://www.wikidata.org/entity/statement/Q34521260-1D564C22-09F0-4409-B035-386CFBA0A607
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma.
P2860
Q34521260-1D564C22-09F0-4409-B035-386CFBA0A607
BestRank
Statement
http://www.wikidata.org/entity/statement/Q34521260-1D564C22-09F0-4409-B035-386CFBA0A607
rank
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type
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wasDerivedFrom
bd5c1c72aa6ebb81eb366a75c0ecaaddf4ce3eb3
P2860
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells