A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma.
about
Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924).Ubiquitination in melanoma pathogenesis and treatment.Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides.Proteasome-associated deubiquitinases and cancer.Systemic inhibition of neddylation by 3-day MLN4924 treatment regime does not impair autophagic flux in mouse hearts and brains.Protein neddylation and its alterations in human cancers for targeted therapy.Neddylation inhibitor MLN4924 induces G2 cell cycle arrest, DNA damage and sensitizes esophageal squamous cell carcinoma cells to cisplatin.Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.Blocking PD1/PDL1 Interactions Together with MLN4924 Therapy is a Potential Strategy for Glioma Treatment
P2860
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P2860
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma.
description
2016 nî lūn-bûn
@nan
2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
A phase I study of the investi ...... ents with metastatic melanoma.
@ast
A phase I study of the investi ...... ents with metastatic melanoma.
@en
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat
@nl
type
label
A phase I study of the investi ...... ents with metastatic melanoma.
@ast
A phase I study of the investi ...... ents with metastatic melanoma.
@en
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat
@nl
prefLabel
A phase I study of the investi ...... ents with metastatic melanoma.
@ast
A phase I study of the investi ...... ents with metastatic melanoma.
@en
A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat
@nl
P2093
P2860
P1476
A phase I study of the investi ...... ents with metastatic melanoma.
@en
P2093
Anna C Pavlick
Bruce J Dezube
George Mulligan
Hélène Faessel
John A Thompson
Michael D Pickard
Omid Hamid
Peter Boasberg
Shailender Bhatia
P2860
P2888
P304
P356
10.1007/S10637-016-0348-5
P577
2016-04-08T00:00:00Z
P6179
1005584743