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1
Q34827947-B0BB0B5A-04C9-479C-9C23-F27BE9A0DDAD
Q34827947-B0BB0B5A-04C9-479C-9C23-F27BE9A0DDAD
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http://www.wikidata.org/entity/statement/Q34827947-B0BB0B5A-04C9-479C-9C23-F27BE9A0DDAD
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
P2860
Q34827947-B0BB0B5A-04C9-479C-9C23-F27BE9A0DDAD
BestRank
Statement
http://www.wikidata.org/entity/statement/Q34827947-B0BB0B5A-04C9-479C-9C23-F27BE9A0DDAD
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type
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wasDerivedFrom
9a4e5627f37a9dce0862cd80907f6b2dbf8435fa
P2860
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.