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Q37000556-07F5F3E0-E6B4-4F08-8CAD-B038E4A09386
Q37000556-07F5F3E0-E6B4-4F08-8CAD-B038E4A09386
BestRank
Statement
http://www.wikidata.org/entity/statement/Q37000556-07F5F3E0-E6B4-4F08-8CAD-B038E4A09386
An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R.
P2860
Q37000556-07F5F3E0-E6B4-4F08-8CAD-B038E4A09386
BestRank
Statement
http://www.wikidata.org/entity/statement/Q37000556-07F5F3E0-E6B4-4F08-8CAD-B038E4A09386
rank
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type
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wasDerivedFrom
f687a2f594d338a81c0667fd236967cee4b9e8df
P2860
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.