An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
about
Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding propertiesStructure and allosteric regulation of the X 2 integrin I domainStructural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1Structure ofStreptococcus agalactiaetip pilin GBS104: a model for GBS pili assembly and host interactionsAssociation of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive stateComplement activation in factor D-deficient miceEndothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesionStructural basis of integrin regulation and signalingA small molecule agonist of an integrin, alphaLbeta2.Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.Adhesive dynamicsAnthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen bindingI-domain of lymphocyte function-associated antigen-1 mediates rolling of polystyrene particles on ICAM-1 under flow.Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domainSedative drug modulates T-cell and lymphocyte function-associated antigen-1 function.Integrin structure: new twists and turns in dynamic cell adhesion.Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity stateAL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.Organization of the integrin LFA-1 in nanoclusters regulates its activity.Importance of force linkage in mechanochemistry of adhesion receptors.The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsRegulation of integrin affinity on cell surfacesReconstruction of integrin activation.Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesionIsoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.Integrin antagonists as therapeutics for inflammatory diseases.Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletionsT-cell migration: a naive paradigm?Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R.Identification of integrin beta subunit mutations that alter heterodimer function in situ.The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavityLFA-1 binding destabilizes the JAM-A homophilic interaction during leukocyte transmigration.Adhesive dynamics simulation of G-protein-mediated chemokine-activated neutrophil adhesion.Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1.Neutrophil arrest by LFA-1 activationTransmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.
P2860
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P2860
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
An isolated, surface-expressed ...... rmation with a disulfide bond.
@ast
An isolated, surface-expressed ...... rmation with a disulfide bond.
@en
An isolated, surface-expressed ...... rmation with a disulfide bond.
@nl
type
label
An isolated, surface-expressed ...... rmation with a disulfide bond.
@ast
An isolated, surface-expressed ...... rmation with a disulfide bond.
@en
An isolated, surface-expressed ...... rmation with a disulfide bond.
@nl
prefLabel
An isolated, surface-expressed ...... rmation with a disulfide bond.
@ast
An isolated, surface-expressed ...... rmation with a disulfide bond.
@en
An isolated, surface-expressed ...... rmation with a disulfide bond.
@nl
P2093
P2860
P356
P1476
An isolated, surface-expressed ...... ormation with a disulfide bond
@en
P2093
P2860
P304
P356
10.1073/PNAS.041606398
P407
P50
P577
2001-02-01T00:00:00Z