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Q38972586-41347163-5979-4126-8571-A586A8B5AF92
Q38972586-41347163-5979-4126-8571-A586A8B5AF92
BestRank
Statement
http://www.wikidata.org/entity/statement/Q38972586-41347163-5979-4126-8571-A586A8B5AF92
Cysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity.
P2860
Q38972586-41347163-5979-4126-8571-A586A8B5AF92
BestRank
Statement
http://www.wikidata.org/entity/statement/Q38972586-41347163-5979-4126-8571-A586A8B5AF92
rank
NormalRank
type
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Statement
wasDerivedFrom
e867c1ea98457b5b568ec182a13b1625fc025164
P2860
The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together