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Q52366350-6FC674DF-ADC9-4A4E-97A6-1DC407E571AB
Q52366350-6FC674DF-ADC9-4A4E-97A6-1DC407E571AB
BestRank
Statement
http://www.wikidata.org/entity/statement/Q52366350-6FC674DF-ADC9-4A4E-97A6-1DC407E571AB
FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway.
P2860
Q52366350-6FC674DF-ADC9-4A4E-97A6-1DC407E571AB
BestRank
Statement
http://www.wikidata.org/entity/statement/Q52366350-6FC674DF-ADC9-4A4E-97A6-1DC407E571AB
rank
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wasDerivedFrom
93b14bbf04268731332e9dd346b447de36b49ee7
P2860
The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.