SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationThrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneThe pseudokinase MLKL mediates necroptosis via a molecular switch mechanismGrowth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cellsSOCS2 negatively regulates growth hormone action in vitro and in vivoThe critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12Architectural defects in the spleens of Nkx2-3-deficient mice are intrinsic and associated with defects in both B cell maturation and T cell-dependent immune responsesSuppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signalingAgm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and developmentMonocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cellsGenetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory diseasePoint mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- miceFas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activityA mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Programmed anuclear cell death delimits platelet life span.Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Thrombopoietin and hematopoietic stem cells.Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potentialPlatelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice.A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells.Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment.Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.Crowding-dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cellsInactivation of PU.1 in adult mice leads to the development of myeloid leukemiaElevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.Regulation of hematopoietic stem cells by their mature progenyThe absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes.Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.Hematopoietic cytokines.
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description
Australian medical researcher
@en
australischer Physiologe, Hämatologe und Krebsforscher
@de
immunoloog uit Australië (1929-2014)
@nl
taighdeoir leighis Astrálach
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name
Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
@de
Donald Metcalf
@en
Donald Metcalf
@es
Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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type
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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altLabel
D Metcalf
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D. Metcalf
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Metcalf D
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Metcalf D.
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Metcalf
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prefLabel
Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
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Donald Metcalf
@fr
Donald Metcalf
@ga
Donald Metcalf
@it
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