The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
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A critical role for the transcription factor Scl in platelet production during stress thrombopoiesisTargets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesisETO2 coordinates cellular proliferation and differentiation during erythropoiesisGenetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell FunctionStructural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional TargetsErythro-megakaryocytic transcription factors associated with hereditary anemiaAdult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survivalTwist-2 controls myeloid lineage development and functionRFP represses transcriptional activation by bHLH transcription factorsMef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasisThe TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursorsThe essential haematopoietic transcription factor Scl is also critical for neuronal developmentSCL and associated proteins distinguish active from repressive GATA transcription factor complexesDecoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish.Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesisNovel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish modelsUsing cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation.Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment.Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression.Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesisMegakaryocytes and beyond: the birth of platelets.A requirement for Lim domain binding protein 1 in erythropoiesis.Murine erythroid short-term radioprotection requires a BMP4-dependent, self-renewing population of stress erythroid progenitors.Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice.Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells.MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing.The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesisAryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions.Role of helix-loop-helix proteins during differentiation of erythroid cells.Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.
P2860
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P2860
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
description
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2003
@ast
im Februar 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/02/04)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/02/04)
@nl
наукова стаття, опублікована в лютому 2003
@uk
name
The critical regulator of embr ...... and lineage choice in CFU-S12
@ast
The critical regulator of embr ...... and lineage choice in CFU-S12
@en
The critical regulator of embr ...... and lineage choice in CFU-S12
@nl
type
label
The critical regulator of embr ...... and lineage choice in CFU-S12
@ast
The critical regulator of embr ...... and lineage choice in CFU-S12
@en
The critical regulator of embr ...... and lineage choice in CFU-S12
@nl
prefLabel
The critical regulator of embr ...... and lineage choice in CFU-S12
@ast
The critical regulator of embr ...... and lineage choice in CFU-S12
@en
The critical regulator of embr ...... and lineage choice in CFU-S12
@nl
P2093
P2860
P50
P356
P1476
The critical regulator of embr ...... and lineage choice in CFU-S12
@en
P2093
C Glenn Begley
Lorraine Robb
Mark A Hall
Stephen M Jane
P2860
P304
P356
10.1073/PNAS.0237324100
P407
P577
2003-01-27T00:00:00Z