sameAs
Perspectives on anti-CD47 antibody treatment for experimental cancerBatf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityCD2-associated protein haploinsufficiency is linked to glomerular disease susceptibilityListeriolysin o is strongly immunogenic independently of its cytotoxic activityDendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC moleculesAutoantibodies and CD4 T cells target a beta cell retroviral envelope protein in non-obese diabetic mice.Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity.IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes.Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cellsListeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in miceActivated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells.The central role of antigen presentation in islets of Langerhans in autoimmune diabetesDistinct recognition by two subsets of T cells of an MHC class II-peptide complex.ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditionsEarly, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model.Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph nodeImmunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells.Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response.Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans.Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouseRNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in micePerspective on antigen processing and presentation.Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes.Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competitionCD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model.Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells.Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletionProcessing of proteins in autophagy vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system.Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes.Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?Conformational isomers of a peptide-class II major histocompatibility complex.The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection.The wide diversity and complexity of peptides bound to class II MHC molecules.Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells.Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction.Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants.
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ahli biologi asal Amerika Serikat
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kubanisch-US-amerikanischer Pathologe und Immunologe
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Emil R. Unanue
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Emil R. Unanue
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Emil R Unanue
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Emil Raphael Unanue
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