sameAs
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hostsNef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1TRIM proteins regulate autophagy and can target autophagic substrates by direct recognitionSemen-derived amyloid fibrils drastically enhance HIV infectionPremature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensingEvolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx proteinFibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancerDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptideShort-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptideDiscovery and characterization of an endogenous CXCR4 antagonistEarly Vertebrate Evolution of the Host Restriction Factor TetherinDirect visualization of HIV-enhancing endogenous amyloid fibrils in human semen.Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance.Differential Control of BST2 Restriction and Plasmacytoid Dendritic Cell Antiviral Response by Antagonists Encoded by HIV-1 Group M and O Strains.Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain.Tetherin antagonism by primate lentiviral nef proteins.HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef.Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptationReacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee hostHuman tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu functionInefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infectionA flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells.Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection).Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virusLiquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection.Human immunodeficiency virus type 1 inhibits DNA damage-triggered apoptosis by a Nef-independent mechanism.Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells.Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication.Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.Link between primate lentiviral coreceptor usage and Nef function.Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophagesGenetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeysT-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques.
P50
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P50
description
Duits professor
@nl
German virologist
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German virologist
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German virologist
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deutscher Virologe
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virólogo alemán
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հետազոտող
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عالم فيروسات ألماني
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name
Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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type
label
Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
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Frank Kirchhoff
@nl
Frank Kirchhoff
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Frank Kirchhoff
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prefLabel
Frank Kirchhoff
@ast
Frank Kirchhoff
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Frank Kirchhoff
@de
Frank Kirchhoff
@en
Frank Kirchhoff
@es
Frank Kirchhoff
@fr
Frank Kirchhoff
@it
Frank Kirchhoff
@nl
Frank Kirchhoff
@pt
Frank Kirchhoff
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P106
P227
P19
P21
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0000 0000 1284 6223
P214
P227
P31
P496
0000-0002-7052-2360
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P569
1961-04-24T00:00:00Z
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viaf-74696830