Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide
about
Molecular targets for flavivirus drug discoveryAccidental discovery and isolation of Zika virus in Uganda and the relentless epidemiologist behind the investigationsAcute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threatsExpanding the clinical indications for α(1)-antitrypsin therapyAlpha-1-antitrypsin interacts with gp41 to block HIV-1 entry into CD4+ T lymphocytes.A virocidal amphipathic -helical peptide that inhibits hepatitis C virus infection in vitroStructures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeShort-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptideMechanisms and modifications of naturally occurring host defense peptides for anti-HIV microbicide developmentInternal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scalesIdentification of a PA-binding peptide with inhibitory activity against influenza A and B virus replicationHIV-1 fusion is blocked through binding of GB Virus C E2-derived peptides to the HIV-1 gp41 disulfide loop [corrected]Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workersα1Proteinase inhibitor regulates CD4+ lymphocyte levels and is rate limiting in HIV-1 diseaseIdentification of high-affinity PB1-derived peptides with enhanced affinity to the PA protein of influenza A virus polymeraseComputational prediction of anti HIV-1 peptides and in vitro evaluation of anti HIV-1 activity of HIV-1 P24-derived peptides.Vpu matchmakers as a therapeutic strategy for HIV infection.Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infectionElevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infectionDevelopment of topical microbicides to prevent the sexual transmission of HIVThe three lives of viral fusion peptidesA comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa.Anti-HSV activity of serpin antithrombin III.Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses.The SCHOOL of nature: III. From mechanistic understanding to novel therapiesA peptide inhibitor of cytomegalovirus infection from human hemofiltrateHIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by α-1-antitrypsin through altered IκBα ubiquitinationPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques.Discovery of modulators of HIV-1 infection from the human peptidome.Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor designAlpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques.Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4.Assessment of RNA carrier function in peptide amphiphiles derived from the HIV fusion peptideHuman seminal plasma abrogates the capture and transmission of human immunodeficiency virus type 1 to CD4+ T cells mediated by DC-SIGN.Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.Low-density lipoprotein receptor-related protein 1 mediates α1-antitrypsin internalization in CD4+ T lymphocytes.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41Recent progress in antiretrovirals--lessons from resistance
P2860
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P2860
Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide
description
2007 nî lūn-bûn
@nan
2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Discovery and optimization of ...... geting the gp41 fusion peptide
@ast
Discovery and optimization of ...... geting the gp41 fusion peptide
@en
Discovery and optimization of ...... geting the gp41 fusion peptide
@nl
type
label
Discovery and optimization of ...... geting the gp41 fusion peptide
@ast
Discovery and optimization of ...... geting the gp41 fusion peptide
@en
Discovery and optimization of ...... geting the gp41 fusion peptide
@nl
prefLabel
Discovery and optimization of ...... geting the gp41 fusion peptide
@ast
Discovery and optimization of ...... geting the gp41 fusion peptide
@en
Discovery and optimization of ...... geting the gp41 fusion peptide
@nl
P2093
P50
P3181
P1433
P1476
Discovery and optimization of ...... geting the gp41 fusion peptide
@en
P2093
Axel Schulz
Bernd Meyer
Chawaree Chaipan
Dennis Wilhelm
Knut Adermann
Michael Schindler
Raghavan Chinnadurai
Thomas Peters
P304
P3181
P356
10.1016/J.CELL.2007.02.042
P407
P577
2007-04-20T00:00:00Z