OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice - Test2 - elhamkhani - TriplyDB

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

http://www.wikidata.org/entity/Q21090145

about

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness The mechanism of action of PA-824: Novel insights from transcriptional profiling PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release New agents for the treatment of drug-resistant Mycobacterium tuberculosis Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions Management of multidrug-resistant TB: novel treatments and their expansion to low resource settings Delamanid expanded access novel treatment of drug resistant tuberculosis The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Next-generation antimicrobials: from chemical biology to first-in-class drugs Antituberculosis therapy for 2012 and beyond Nitroimidazoles for the treatment of TB: past, present and future Tuberculosis drug discovery in the post-post-genomic era Rising to the challenge: new therapies for tuberculosis Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824 Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen Towards a new combination therapy for tuberculosis with next generation benzothiazinones Inactivation of the Mycobacterium tuberculosis Antigen 85 Complex by Covalent, Allosteric Inhibitors Current strategies to treat tuberculosis Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds Heightened vulnerability to MDR-TB epidemics after controlling drug-susceptible TB Discovery of novel MDR-Mycobacterium tuberculosis inhibitor by new FRIGATE computational screen Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis Bactericidal activity of an imidazo[1, 2-a]pyridine using a mouse M. tuberculosis infection model Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis glpx Gene in Mycobacterium tuberculosis Is Required for In Vitro Gluconeogenic Growth and In Vivo Survival New anti-tuberculosis drugs and regimens: 2015 update Pipeline of drugs for related diseases: tuberculosis New antimycobacterial agents in the pre-clinical phase or beyond: recent advances in patent literature (2001-2016).Tuberculosis therapy for 2016 and beyond.Antibiotics in the clinical pipeline at the end of 2015.Insights into the pharmacokinetic properties of antitubercular drugs.Recent advances in tuberculosis: New drugs and treatment regimens.Exploring prospects of novel drugs for tuberculosis.Delamanid: a review of its use in patients with multidrug-resistant tuberculosis.A synthetic mammalian gene circuit reveals antituberculosis compounds.Ensuring the involvement of children in the evaluation of new tuberculosis treatment regimens Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

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OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

http://www.wikidata.org/entity/Q21090145

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2006 nî lūn-bûn

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Hirofumi Sasaki

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Hiroyuki Hashizume

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Makoto Matsumoto

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Masanori Kawasaki

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Tatsuo Tomishige

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Yoshihiko Shimokawa

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P2860

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

In vitro and in vivo activities of the nitroimidazole CGI 17341 against Mycobacterium tuberculosis

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

Nitroimidazole drugs-action and resistance mechanisms I. Mechanism of action

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

Global tuberculosis incidence and mortality during 1990-2000.

The global situation of MDR-TB.

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