Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
about
Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowthIdentification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neuronsGDNF is a fast-acting potent inhibitor of alcohol consumption and relapseNeuroprotective Transcription Factors in Animal Models of Parkinson DiseaseGDNF is not required for catecholaminergic neuron survival in vivoGDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseGDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson's diseasePro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neuronsAn Efficient and Versatile System for Visualization and Genetic Modification of Dopaminergic Neurons in Transgenic MiceDiminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice.c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.Neuroregeneration in neurodegenerative disorders.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Retinal TrkB receptors regulate neural development in the inner, but not outer, retinaCompromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning.Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3.Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos.A molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype.BDNF is a negative modulator of morphine action.α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration.Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.Intracellular signalling pathways in dopamine cell death and axonal degeneration.NURR1 in Parkinson disease--from pathogenesis to therapeutic potential.Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction.Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.Progressive postnatal motoneuron loss in mice lacking GDF-15.Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuitParkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degenerationAlternative splicing results in RET isoforms with distinct trafficking properties.RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals.Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation.Structure and physiology of the RET receptor tyrosine kinase.Critical role of GFRα1 in the development and function of the main olfactory systemParkin deficiency increases vulnerability to inflammation-related nigral degenerationStress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism.Parkinson's disease: genetic versus toxin-induced rodent models.Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor, GFR alpha1, gene
P2860
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P2860
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@ast
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en-gb
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@nl
type
label
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@ast
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en-gb
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@nl
prefLabel
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@ast
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en-gb
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@nl
P2093
P2860
P3181
P1433
P1476
Absence of Ret signaling in mi ...... on of the nigrostriatal system
@en
P2093
Geert M J Ramakers
Klaus Beyer
Liviu Aron
Marten P Smidt
Sabine Seitz
Xiaoxi Zhuang
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0050039
P407
P577
2007-03-01T00:00:00Z