Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies - Test2 - elhamkhani - TriplyDB

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

http://www.wikidata.org/entity/Q24554351

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Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo Mitochondria: A Therapeutic Target for Parkinson's Disease?The role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelism Genetically engineered mouse models of Parkinson's disease Early Parkinson's disease symptoms in α-synuclein transgenic monkeys.Neuropathology in mice expressing mouse alpha-synuclein Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation Value of genetic models in understanding the cause and mechanisms of Parkinson's disease Animal models of Parkinson's disease: vertebrate genetics Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein.Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Phosphorylation of synucleins by members of the Polo-like kinase family.Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegeneration Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease.A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation Residue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Spinal cord pathology in alpha-synuclein transgenic mice Direct observation of the interconversion of normal and toxic forms of α-synuclein Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model t

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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

http://www.wikidata.org/entity/Q24554351

description

2002 nî lūn-bûn

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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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name

Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Misfolded proteinase K-resista ...... human alpha-synucleinopathies

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Benoit I Giasson

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Edilio Borroni

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Hans A Kretzschmar

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Hideo Fujiwara

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Laurence Ozmen

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Masato Hasegawa

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Philipp J Kahle

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Sabine Odoy

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Takeshi Iwatsubo

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Veronika Müller

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

Alpha-synuclein and neurodegenerative diseases

Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

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1429-39

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3628637

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10.1172/JCI15777

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10.1172/JCI200215777

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10

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Christian Haass

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2002-11-01T00:00:00Z

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