Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
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Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal systemPhosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of ParkinsonismPolo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivoMitochondria: A Therapeutic Target for Parkinson's Disease?The role of free radicals in the aging brain and Parkinson's Disease: convergence and parallelismGenetically engineered mouse models of Parkinson's diseaseEarly Parkinson's disease symptoms in α-synuclein transgenic monkeys.Neuropathology in mice expressing mouse alpha-synucleinImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceSelective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brainCasein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formationAssociation of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathiesParkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathyResistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activationValue of genetic models in understanding the cause and mechanisms of Parkinson's diseaseAnimal models of Parkinson's disease: vertebrate geneticsGamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein.Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma.Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model.Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulationGlial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?Phosphorylation of synucleins by members of the Polo-like kinase family.Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegenerationSynphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse modelProgressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease.A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formationResidue histidine 50 plays a key role in protecting α-synuclein from aggregation at physiological pH.Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Spinal cord pathology in alpha-synuclein transgenic miceDirect observation of the interconversion of normal and toxic forms of α-synucleinTau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model t
P2860
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P2860
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@ast
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@en
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@nl
type
label
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@ast
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@en
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@nl
prefLabel
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@ast
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@en
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@nl
P2093
P2860
P50
P3181
P1476
Misfolded proteinase K-resista ...... human alpha-synucleinopathies
@en
P2093
Benoit I Giasson
Edilio Borroni
Hans A Kretzschmar
Hideo Fujiwara
Laurence Ozmen
Masato Hasegawa
Philipp J Kahle
Sabine Odoy
Takeshi Iwatsubo
Veronika Müller
P2860
P304
P3181
P356
10.1172/JCI15777
10.1172/JCI200215777
P407
P577
2002-11-01T00:00:00Z