Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice
about
Crystal structure of the Golgi casein kinaseA Single Kinase Generates the Majority of the Secreted PhosphoproteomeSecreted protein kinasesDentin Matrix Proteins in Bone Tissue EngineeringDysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp miceA unified model for bone-renal mineral and energy metabolismFibroblast Growth Factor-23-A Potential Uremic ToxinThe secretory pathway kinasesThe Raine syndrome protein FAM20C is a Golgi kinase that phosphorylates bio-mineralization proteinsAmelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null micePHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolismSpecific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.The specific role of FAM20C in amelogenesisThe specific role of FAM20C in dentinogenesis.Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.SPR4-peptide alters bone metabolism of normal and HYP mice.Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysisVariability of systemic and oro-dental phenotype in two families with non-lethal Raine syndrome with FAM20C mutations.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin FormationMolecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes.FAM20C plays an essential role in the formation of murine teethHereditary hypophosphatemia in Norway: a retrospective population-based study of genotypes, phenotypes, and treatment complications.Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in boneTransgenic expression of dentin phosphoprotein inhibits skeletal development.Systemic Control of Bone Homeostasis by FGF23 Signaling.1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression.Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.FAM20A binds to and regulates FAM20C localizationLoss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowthInactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects.Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilageImmortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.Inflammation regulates fibroblast growth factor 23 production.Multilineage somatic activating mutations in HRAS and NRAS cause mosaic cutaneous and skeletal lesions, elevated FGF23 and hypophosphatemia.The rachitic tooth.Phosphorylation of substrates destined for secretion by the Fam20 kinases.Casein kinase: the triple meaning of a misnomer.Sclerosing bone dysplasias: leads toward novel osteoporosis treatments.
P2860
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P2860
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@ast
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en-gb
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@nl
type
label
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@ast
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en-gb
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@nl
prefLabel
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@ast
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en-gb
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@nl
P2093
P2860
P3181
P1433
P1476
Inactivation of a novel FGF23 ...... pophosphatemic rickets in mice
@en
P2093
Afsaneh Rangiani
Baozhi Yuan
Changcheng Li
Chunlin Qin
Jay Groppe
Jian Q Feng
Jianjun Hao
Suzhen Wang
Xiaofang Wang
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002708
P407
P50
P577
2012-01-01T00:00:00Z